Open Access<p>Up-Regulation of MicroRNA-21 Indicates Poor Prognosis and Promotes Cell Proliferation in Esophageal Squamous Cell Carcinoma via Upregulation of lncRNA SNHG1</p>
Author(s) -
Dongbo Luo,
Zhenyi Huang,
Haiyan Lv,
Yang Wang,
Wei Sun,
Xiaohong Sun
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s221731
Subject(s) - microrna , downregulation and upregulation , cancer research , biology , cell , cell growth , stage (stratigraphy) , metastasis , medicine , gene , cancer , genetics , paleontology
MicroRNA-21 (miRNA-21) and lncRNA SNHG1 (small nucleolar RNA host gene 1) are known to be aberrantly upregulated and promote tumor progression in various cancers. Nevertheless, very few studies have determined the roles of tissue and circulating miRNA-21 and SNHG1 in ESCC patients. Particularly, knowledge about the characteristics of miRNA-21 and SNHG1 expression and their correlations with survival rates, as well as their interaction with each other remains inadequate in ESCC.