Open Access<p>GALE Promotes the Proliferation and Migration of Glioblastoma Cells and Is Regulated by miR-let-7i-5p</p>
Author(s) -
Xiangrong Sun,
Hao Xue,
Ye Xiong,
Rui Yu,
Xiao Gao,
Mingyu Qian,
Shaobo Wang,
Huizhi Wang,
Jianye Xu,
Zihang Chen,
Lin Deng,
Gang Li
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s221585
Subject(s) - u87 , gene knockdown , glioma , glioblastoma , cancer research , cell growth , downregulation and upregulation , microrna , in vivo , apoptosis , cell culture , small interfering rna , transfection , biology , medicine , chemistry , gene , genetics
Glioma is the most common and lethal type of brain tumor. While GALE (UDP-galactose-4-epimerase) has been shown to be overexpressed in some kinds of cancers, its expression in gliomas has not been reported. MicroRNAs (miRNAs) function as tumor suppressors in many cancers, and online datasets can be used to predict whether GALE is regulated by miR-let-7i-5p. In this investigation, we explored the effect and regulatory mechanisms of GALE on glioblastoma growth via miR-let-7i-5p.