Open Access<p>Cervical Cancer Cells-Secreted Exosomal microRNA-221-3p Promotes Invasion, Migration and Angiogenesis of Microvascular Endothelial Cells in Cervical Cancer by Down-Regulating MAPK10 Expression</p>
Author(s) -
Lu Zhang,
Huihui Li,
Man Yuan,
Mingbao Li,
Shuquan Zhang
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s221527
Subject(s) - angiogenesis , microvesicles , microrna , cancer research , western blot , biology , cell migration , cell growth , reporter gene , cervical cancer , cell , microarray analysis techniques , gene expression , cancer , gene , genetics
Cervical cancer (CC) is recognized as a common cancer with a high risk worldwide. Exosomal microRNAs (miRNAs) have received attention for their increasing potentials in CC therapy. In this study, we identify the involvement of miR-221-3p in CC progression by affecting angiogenesis of microvascular endothelial cells (MVECs).