Open Access<p>Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial–Mesenchymal Transition In Gastric Cancer</p>
Author(s) -
Di Feng,
Xiaoyu Yu,
Xing Tian,
Hongxue Meng,
Yang Jiang,
Haoming Song,
WenQi Li,
Haocheng Zhang,
Jingshu Geng
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s221422
Subject(s) - vimentin , cancer research , epithelial–mesenchymal transition , oncogene , cd44 , catenin , cancer , metastasis , biology , carcinogenesis , beta catenin , immunohistochemistry , cell , cell cycle , wnt signaling pathway , microbiology and biotechnology , immunology , signal transduction , genetics
Metadherin (MTDH), as an oncogene, is associated with metastasis and poor prognosis. This study investigated MTDH expressions and development of gastric cancer (GC) cell phenotypes and the contribution of MTDH to epithelial-mesenchymal transition (EMT).