Open Access<p>miR-194 Inhibits the Proliferation of SW620 Colon Cancer Stem Cells Through Downregulation of SSH2 Expression</p>
Author(s) -
Bo Sun,
Yantian Fang,
Danjuan Jin,
Zongyou Chen,
Zhenyang Li,
Xiaodong Gu,
Jianbin Xiang
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s221150
Subject(s) - stem cell , cd44 , cancer stem cell , cancer research , stem cell marker , biology , cell growth , colorectal cancer , apoptosis , microbiology and biotechnology , cell , cancer , genetics
Colorectal cancer (CRC) stem cells are tumorigenic, capable of self-renewal, and resistant to therapy. Although the expression pattern and functions of micro RNA (miR)-194 in CRC cells have been widely investigated, little is known about its role in CRC stem cells. Therefore, the aim of this study was to investigate the potential role of miR-194 in CRC stem cells.