Open Access<p>Increased Stromal Infiltrating Lymphocytes are Associated with Circulating Tumor Cells and Metastatic Relapse in Breast Cancer Patients After Neoadjuvant Chemotherapy</p>
Author(s) -
Jiawei Liu,
Yixin Xu,
Mengxue Yu,
Liang Zhao,
Yi Xu,
Ge Ma,
Wenbin Zhou,
Pengfei Kong,
Lijun Ling,
Shui Wang,
Hong Pan,
Yi Zhao
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s220327
Subject(s) - medicine , circulating tumor cell , breast cancer , metastatic breast cancer , stromal cell , chemotherapy , tumor infiltrating lymphocytes , oncology , metastasis , cd8 , cancer , pathology , immune system , immunotherapy , immunology
Circulating tumor cells (CTCs) intravasate into the bloodstream throughout early cancer stages, promoting metastasis. The tumor microenvironment plays a crucial role in disease progression and outcome. The aim of this prospective study was to investigate the associations of intratumoral and stromal tumor-infiltrating lymphocytes (TILs) with CTCs among patients receiving neoadjuvant chemotherapy (NAC).