Open Access<p>Infiltrating CD4 and CD8 lymphocytes in HPV infected uterine cervical milieu</p>
Author(s) -
Ninu Maskey,
Niresh Thapa,
Muna Maharjan,
Girishma Shrestha,
Narayani Maharjan,
Hongwei Cai,
Shangqin Liu
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s217264
Subject(s) - tumor infiltrating lymphocytes , cervix , cd8 , cervical intraepithelial neoplasia , medicine , stromal cell , stroma , pathology , cervical cancer , immunology , immune system , cancer , immunohistochemistry
Tumor infiltrating lymphocytes (TILs) have been extensively described in anti-tumor immunity, but their functional alterations in the immunoediting processes during neoplastic progression in the uterine cervix are still not clear. Our aim was to gain insight into cervical tissue T cell populations, determine if there are any differences in the localization and quantity distribution of T lymphocytes, and to evaluate their role in disease regression or progression in the cervical neoplastic milieu.