Open Access<p>A New Regulatory Mechanism Between P53 And YAP Crosstalk By SIRT1 Mediated Deacetylation To Regulate Cell Cycle And Apoptosis In A549 Cell Lines</p>
Author(s) -
Fang Yuan,
Jinliang Wang,
Ruixin Li,
Xiao Zhao,
Yuxuan Zhang,
Biao Liu,
Yonghong Lei,
Yi Hu
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s214826
Subject(s) - crosstalk , acetylation , microbiology and biotechnology , apoptosis , chemistry , cell cycle , mechanism (biology) , biology , biochemistry , physics , gene , optics , quantum mechanics
Yes-associated protein (YAP) is downstream of the Hippo signaling pathway, which regulates several cellular processes. P53 is a key transcriptional regulator that responds to a variety of cellular stresses and regulates key cellular processes such as DNA repair, cell-cycle progression, angiogenesis, and apoptosis. Overexpression of YAP antagonizes P53 activity and targets its expression. However, the mechanism that underlies the post-transcriptional crosstalk between P53 and YAP has not been well dissected.