Open Access<p>Reciprocal Role Of DNA Methylation And Sp1 Binding In Ki-67 Gene Transcription</p>
Author(s) -
Liantao Li,
Xun Wang,
Wentao Zhu,
Guowei Qian,
DongSheng Pei,
Junnian Zheng
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s213769
Subject(s) - dna methylation , methylation , transcription (linguistics) , promoter , reciprocal , gene , microbiology and biotechnology , transcription factor , chemistry , biology , genetics , gene expression , linguistics , philosophy
DNA methylation plays major regulatory roles in gene transcription. Our previous studies confirmed that Ki-67 promoter is hypomethylated and Sp1 is a transcriptional activator of Ki-67 gene in cancer cells. However, whether Sp1-mediated transcriptional activation of Ki-67 is related to its methylation has not been studied yet.