Open Access<p>The Effects of Matrine in Combination with Docetaxel on Castration-Resistant (Androgen-Independent) Prostate Cancer</p>
Author(s) -
Qi Li,
Jia Xu,
Zheng He,
Wei Xue,
Fengmei Wang,
Peng Zhāng,
Jun Li,
Bei Song,
Qingyong Wang,
Ronghai Li,
Hai Huang
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s213419
Subject(s) - du145 , matrine , docetaxel , prostate cancer , androgen deprivation therapy , pharmacology , medicine , flow cytometry , western blot , apoptosis , cancer , cancer cell , chemistry , immunology , lncap , biochemistry , psychiatry , gene
Matrine (MAT) exhibits higher efficacy of chemotherapy when it is combined with other chemotherapeutic drugs; however, the therapeutic efficacy of matrine in combination with docetaxel (DOC) for prostate cancer, or even androgen-independent prostate cancer, remains poorly understood and the underlying molecular mechanisms have not yet been clearly defined. In the present study, we investigated whether matrine combined with docetaxel can strengthen anti-cancer effect.