Open Access<p>Lack of Efficacy: When Opioids Do Not Achieve Analgesia from the Beginning of Treatment in Cancer Patients</p>
Author(s) -
Oscar Corli,
Giovanna Damia,
Francesca Galli,
Carmen Verrastro,
Massimo Broggini
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s211818
Subject(s) - medicine , analgesic , post hoc analysis , opioid , cancer pain , adverse effect , anesthesia , cancer , randomized controlled trial , morphine , post hoc , clinical trial , receptor
Opioids are often used to relieve moderate to severe pain, but their analgesic response may vary. We focused on the absolute lack of analgesic response immediately after beginning opioid treatment, quantifying the proportion of patients with unchanged or worse pain on day 3 (defined as early non-responders (ENRs)) and day 7.