Open Access<p>Circulating Tumor Cell Detection In Epithelial Ovarian Cancer Using Dual-Component Antibodies Targeting EpCAM And FRα</p>
Author(s) -
Na Li,
Hao Zuo,
Luojun Chen,
Huali Liu,
Jin Zhou,
Yi Yao,
Bin Xu,
Hongyun Gong,
Yiming Weng,
Qinyong Hu,
Qibin Song,
Min Peng,
Yanxiang Cheng
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s211455
Subject(s) - epithelial cell adhesion molecule , ovarian cancer , antibody , immunomagnetic separation , chemistry , circulating tumor cell , cancer research , epithelial ovarian cancer , cancer , microbiology and biotechnology , medicine , biology , immunology , metastasis
Circulating tumor cell (CTC) detection methods based on epithelial cell adhesion molecule (EpCAM) have low detection rates in epithelial ovarian cancer (EOC). Meanwhile, folate receptor alpha (FRα) has high expression in EOC cells. We explored the feasibility of combining FRα and EpCAM as CTC capture targets in EOC.