Open Access<p>Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor</p>
Author(s) -
Qianqian Chen,
Jiamin Shi,
Ding Zhou,
Qing Xia,
Tiansheng Zheng,
Yanyan Ren,
Ming Li,
Lihong Fan
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s207677
Subject(s) - berberine , apoptosis , cancer research , mapk/erk pathway , in vivo , lung cancer , cell growth , tissue factor , luciferase , cell , medicine , chemistry , cell culture , signal transduction , pharmacology , biology , transfection , oncology , microbiology and biotechnology , biochemistry , coagulation , genetics
Berberine (BBR) from the widely used Chinese herbal medicine Huanglian has an array of pharmacological and biochemical properties, including anti-neoplastic activity. However, the specific mechanisms underlying these properties are unknown. The aim of this study was to explore the anti-tumor mechanisms of BBR in non-small cell lung cancer (NSCLC).