Open Access<p>Efficacy and safety of intraperitoneally administered resveratrol against rat orthotopic ovarian cancers</p>
Author(s) -
Laifu Zhong,
MoLi Wu,
Hong Li,
Jia Liu,
Lizhu Lin
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s206301
Subject(s) - ovarian cancer , in vivo , resveratrol , ethanol , bioavailability , chemistry , pharmacology , medicine , intraperitoneal injection , andrology , cancer , biology , biochemistry , microbiology and biotechnology
Resveratrol (Res) inhibits ovarian cancer (OC) cell growth but its in vivo anti-OC effects are unclear due to the low bioavailability of systemically administered Res. Intraperitoneal administration may overcome this therapeutic dilemma because it makes Res directly affect the abdominal tumors. Ethanol and DMSO are common Res solvents, while their reliability and safety for long-term in vivo treatment remain unknown.