Open Access<p>Ezrin promotes pancreatic cancer cell proliferation and invasion through activating the Akt/mTOR pathway and inducing YAP translocation</p>
Author(s) -
Chunji Quan,
Jie Sun,
Zhenhua Lin,
Tiefieng Jin,
Bing Dong,
Ziqi Meng,
Jinhua Piao
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s202342
Subject(s) - ezrin , pancreatic cancer , pi3k/akt/mtor pathway , cancer research , protein kinase b , cancer , akt2 , pten , signal transduction , biology , medicine , cell , microbiology and biotechnology , akt1 , cytoskeleton , genetics
Ezrin and YAP are abnormally expressed in various cancers, and play pivotal roles in cancer initiation and development. However, the mechanisms of Ezrin in pancreatic cancer have not been fully elucidated. In this study, we aimed to elucidate the functions and mechanisms of Ezrin in the pathogenesis of pancreatic cancer.