Open Access<p>Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy</p>
Author(s) -
Zhenxiong Zhao,
Shuya Bai,
Ronghua Wang,
Si Xiong,
Yawen Li,
Xiju Wang,
Wei Chen,
Bin Cheng
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s197634
Subject(s) - autophagy , homeobox protein nanog , sox2 , cancer research , metastasis , cancer stem cell , cancer cell , stem cell , carcinogenesis , cancer associated fibroblasts , chemistry , biology , microbiology and biotechnology , cancer , medicine , induced pluripotent stem cell , embryonic stem cell , apoptosis , biochemistry , gene
Both cancer-associated fibroblasts (CAFs) and liver cancer stem cells (LCSCs) play an important part in the tumorigenesis, development and metastasis of hepatocellular carcinoma (HCC). Moreover, the stem-like properties in HCC cells could be promoted by CAFs. However, the mechanism remains largely unknown.