Open Access<p>IGF1R facilitates epithelial-mesenchymal transition and cancer stem cell properties in neuroblastoma via the STAT3/AKT axis</p>
Author(s) -
Xiaohui Wang,
Haiying Wu,
Jian Gao,
Xuhui Wang,
Tianhui Gao,
Shufeng Zhang
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s196862
Subject(s) - epithelial–mesenchymal transition , protein kinase b , cancer research , neuroblastoma , mesenchymal stem cell , chemistry , medicine , microbiology and biotechnology , biology , cancer , signal transduction , cell culture , metastasis , genetics
Neuroblastoma (NB) displays the most heterogeneity in clinical manifestation. The insulin-like growth factor 1 receptor (IGF1R) has long been recognized for its role in tumourigenesis and growth. The IGF/IGF1R pathway is important in maintaining cell survival. It is reported that IGF1R participates in the occurrence of NB, but the mechanism is still unclear.