Open Access<p>The role of long non-coding RNA GAS5 in cancers</p>
Author(s) -
Jiali Ji,
Xiaolan Dai,
SaiChing Jim Yeung,
Xuexin He
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s189052
Subject(s) - gas5 , long non coding rna , cancer research , suppressor , malat1 , cancer , biomarker , medicine , cell growth , biogenesis , biology , bioinformatics , rna , gene , genetics
Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 ( GAS5 ) lncRNA can function as a tumor suppressor in several cancers. LncRNA GAS5 is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.