Open Access<p>Natural gypenosides: targeting cancer through different molecular pathways</p>
Author(s) -
Bashir Ahmad,
Suliman Khan,
Ghulam Nabi,
Yaser Gamallat,
Pengyu Su,
Yazeed Jamalat,
Pengfei Duan,
Lunguang Yao
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s185232
Subject(s) - colorectal cancer , medicine , metastasis , chemotherapy , cancer , cancer research , radiation therapy , lung cancer , apoptosis , toxicity , oncology , pharmacology , biology , biochemistry
The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials.