Open AccessElevated Uric Acid Mediates the Effect of Obesity on Hypertension Development: A Causal Mediation Analysis in a Prospective Longitudinal Study
Author(s) -
Conglin Hong,
Qiu Zhang,
Yan Chen,
Ying Lu,
Linan Chen,
Yan He,
Jing Li,
Shengqi Ma,
Jun Jiang,
Xiaolong Zhang,
JianWei Hu,
Yi Ding,
Mingzhi Zhang,
Hao Peng
Publication year - 2022
Publication title -
clinical epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.868
H-Index - 58
ISSN - 1179-1349
DOI - 10.2147/clep.s363429
Subject(s) - hyperuricemia , medicine , obesity , uric acid , mediation , body mass index , blood pressure , gout , endocrinology , metabolic syndrome , prospective cohort study , political science , law
Although elevated uric acid is associated with obesity and considered a predictor of hypertension, the causal linkage between the three metabolic conditions is not very clear. We aim to examine whether elevated uric acid mediates the effects of obesity on hypertension development.