Open Access<p>A Validation of Methods for the Evaluation of Observational Studies of Screening Mammography: An Exploratory Analysis Based on Simulating Screening Cohorts</p>
Author(s) -
Vasily Giannakeas,
Victoria Sopik,
Steven A. Narod
Publication year - 2020
Publication title -
clinical epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.868
H-Index - 58
ISSN - 1179-1349
DOI - 10.2147/clep.s267584
Subject(s) - hazard ratio , medicine , observational study , confidence interval , statistics , mammography , breast cancer screening , covariate , breast cancer , spurious relationship , matching (statistics) , hazard , propensity score matching , proportional hazards model , econometrics , mathematics , cancer , chemistry , organic chemistry
The degree of confidence one should place on non-randomised observational trials studies which estimate the benefit of screening depends on the validity of the analytic method employed. As is the case for all observational trials, screening evaluation studies are subject to bias. The objective of this study was to create a simulated data set and to compare four analytic methods in order to identify the method which was the least biased in terms of estimating the underlying hazard ratio.