Open Access<p>Impact of Being Eligible for Type 2 Diabetes Treatment on All-Cause Mortality and Cardiovascular Events: Regression Discontinuity Design Study</p>
Author(s) -
Inge Petersen,
Sia Kromann Nicolaisen,
Federico Ricciardi,
Manuj Sharma,
Reimar Wernich Thomsen,
Gianluca Baio,
Lars Pedersen
Publication year - 2020
Publication title -
clinical epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.868
H-Index - 58
ISSN - 1179-1349
DOI - 10.2147/clep.s251704
Subject(s) - medicine , hazard ratio , type 2 diabetes , proportional hazards model , diabetes mellitus , danish , mortality rate , demography , confidence interval , endocrinology , sociology , linguistics , philosophy
Individuals with type 2 diabetes (T2D) have a twofold increased risk for cardiovascular events (CVE), and CVE is responsible for nearly 80% of the mortality. Current treatment guidelines state that individuals should immediately initiate antidiabetic treatment and cardiovascular risk-factor management from T2D diagnosis. However, the evidence base is sparse, and randomized trials are unlikely to be conducted. We examined the impact of being eligible for T2D treatment, as determined by the threshold of HbA 1c ≥6.5% (≥48 mmol/mol), on all-cause mortality and CVE. We hypothesised that individuals who were just above this threshold had a lower risk of CVE and all-cause mortality than individuals just below.