Open Access<p>Digital Image Analysis of Ki-67 Stained Tissue Microarrays and Recurrence in Tamoxifen-Treated Breast Cancer Patients</p>
Author(s) -
Nina Egeland,
Kristín Jónsdóttir,
Kristina Lystlund Lauridsen,
Ivar Skaland,
Cathrine F. Hjorth,
Einar Gudlaugsson,
Stephen Hamilton-Dutoit,
Timothy L. Lash,
Deirdre CroninFenton,
Emiel A. M. Janssen
Publication year - 2020
Publication title -
clinical epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.868
H-Index - 58
ISSN - 1179-1349
DOI - 10.2147/clep.s248167
Subject(s) - medicine , breast cancer , oncology , tamoxifen , odds ratio , ki 67 , cancer , tissue microarray , stage (stratigraphy) , docetaxel , immunohistochemistry , paleontology , biology
The proliferation marker Ki-67 has been used as a prognostic marker to separate low- and high-risk breast cancer subtypes and guide treatment decisions for adjuvant chemotherapy. The association of Ki-67 with response to tamoxifen therapy is unclear. High-throughput automated scoring of Ki-67 might enable standardization of quantification and definition of clinical cut-off values. We hypothesized that digital image analysis (DIA) of Ki-67 can be used to evaluate proliferation in breast cancer tumors, and that Ki-67 may be associated with tamoxifen resistance in early-stage breast cancer.