Open Access<p>Role of cigarette smoking in the development of ischemic stroke and its subtypes: a Mendelian randomization study</p>
Author(s) -
Qian Yu,
Ding Ye,
David Wu,
Feng Chen,
Zhen Zeng,
Lihong Ye,
Rui Zhu,
Zhenyu Zhang,
Yingying Mao
Publication year - 2019
Publication title -
clinical epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.868
H-Index - 58
ISSN - 1179-1349
DOI - 10.2147/clep.s215933
Subject(s) - mendelian randomization , medicine , ischemic stroke , stroke (engine) , randomization , cigarette smoking , mendelian inheritance , bioinformatics , clinical trial , genetics , gene , biology , genotype , genetic variants , ischemia , mechanical engineering , engineering
Numerous studies have indicated that smokers have an increased risk of developing ischemic stroke. However, less is known about the causal relationship between cigarette smoking and ischemic stroke subtypes. In the present study, we aim to determine whether genetically predicted cigarette smoking was associated with subtypes of ischemic stroke using Mendelian randomization (MR).