Open AccessThe Mechanism of Bone Remodeling After Bone Aging
Author(s) -
Huankun Fang,
Zhiqin Deng,
Jianquan Liu,
Siyu Chen,
Zhenhan Deng,
WenCui Li
Publication year - 2022
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s349604
Subject(s) - osteoporosis , bone remodeling , medicine , mechanism (biology) , metabolic bone disease , bone remodeling period , homeostasis , senescence , receptor , osteoclast , philosophy , epistemology
Senescence mainly manifests as a series of degenerative changes in the morphological structure and function of the body. Osteoporosis is a systemic bone metabolic disease characterized by destruction of bone microstructure, low bone mineral content, decreased bone strength, and increased brittleness and fracture susceptibility. Osteoblasts, osteoclasts and osteocytes are the main cellular components of bones. However, in the process of aging, due to various self or environmental factors, the body's function and metabolism are disordered, and osteoporosis will appear in the bones. Here, we summarize the mechanism of aging, and focus on the impact of aging on bone remodeling homeostasis, including the mechanism of ion channels on bone remodeling. Finally, we summarized the current clinical medications, targets and defects for the treatment of osteoporosis.