Open AccessOsteogenic Circulating Endothelial Progenitor Cells are Associated with Vascular Aging of the Large Arteries in Rheumatoid Arthritis
Author(s) -
YapHang Chan,
Cheong Ngai,
Yan Chen,
MeiZhen Wu,
YuJuan Yu,
Zhe Zhen,
Kevin Lai,
Ho Yin Chung,
ChakSing Lau,
HungFat Tse,
KaiHang Yiu
Publication year - 2022
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s337118
Subject(s) - medicine , rheumatoid arthritis , progenitor cell , endothelial progenitor cell , arthritis , cardiology , stem cell , microbiology and biotechnology , biology
Rheumatoid arthritis is associated with both abnormal bone metabolism and accelerated vascular aging but a mechanistic link was lacking. This study aims to investigate the role of osteocalcin (OCN)-expressing circulating endothelial progenitor cells (EPCs) in vascular aging, as determined by arterial calcifications in rheumatoid arthritis.