Open AccessMALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose
Author(s) -
Chong Lu,
Yikui Zhao,
Yan Cao,
Li Liu,
Shanshan Wu,
LI Dong-bin,
Shuang Liu,
ShuYuan Xiao,
Yafen Wei,
Xinyu Li
Publication year - 2021
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s304827
Subject(s) - gene knockdown , pi3k/akt/mtor pathway , malat1 , hippocampal formation , phosphorylation , hyperphosphorylation , transfection , western blot , medicine , microbiology and biotechnology , cancer research , downregulation and upregulation , apoptosis , biology , endocrinology , cell culture , signal transduction , biochemistry , gene , genetics , long non coding rna
High glucose (HG)-induced activation of mTOR promotes tau phosphorylation and leads to diabetes-associated dementia. This study aimed to explore the role of metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) in HG-induced neuronal cell injury.