Open AccessHOTAIR/miR-17-5p Axis is Involved in the Propofol-Mediated Cardioprotection Against Ischemia/Reperfusion Injury
Author(s) -
Junyang Chen,
Xuefeng Liu,
Feng Zhao,
Yuxia Hu
Publication year - 2021
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s286429
Subject(s) - hotair , gene knockdown , reperfusion injury , apoptosis , medicine , cardioprotection , western blot , in vivo , lactate dehydrogenase , pharmacology , microbiology and biotechnology , ischemia , cancer research , downregulation and upregulation , biology , long non coding rna , biochemistry , enzyme , gene
Propofol (PPF) ameliorates ischemia/reperfusion (I/R) injury in multiple organs by reducing apoptosis and release of pro-inflammatory cytokines. This study aims to explore the mechanism of PPF in attenuating myocardial ischemia-reperfusion injury (MIRI).