Open Access<p>Genetic Analysis of Chinese Patients with Early-Onset Dementia Using Next-Generation Sequencing</p>
Author(s) -
Lihong Han,
Yaoming Xue,
Yicen Zheng,
Xiaoyan Li,
Ru Lin,
ZhiYing Wu,
QingQing Tao
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s271222
Subject(s) - medicine , sanger sequencing , dementia , genetics , genetic analysis , genetic testing , frontotemporal dementia , dna sequencing , gene , biology , disease
Early-onset dementia (EOD) is a relatively uncommon form of dementia that afflicts people before age 65. Only a few studies analyzing the genetics of EOD have been performed in the Chinese Han population. Diagnosing EOD remains a challenge due to the diverse genetic and clinical heterogeneity of these diseases. The aim of this study was to investigate the genetic spectrum and clinical features of Chinese patients with EOD.