Open AccessMicroRNA-197-3p Inhibits the Osteogenic Differentiation in Osteoporosis by Down-Regulating KLF 10
Author(s) -
Murong You,
Liang Zhang,
Xiaoxiang Zhang,
Yang Fu,
Dong Xing
Publication year - 2021
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s269171
Subject(s) - runx2 , ovariectomized rat , microrna , osteoblast , western blot , osteoporosis , viability assay , reporter gene , transfection , mtt assay , gene expression , medicine , microbiology and biotechnology , cell , endocrinology , chemistry , biology , gene , biochemistry , in vitro , estrogen
Studies have shown that microRNA (miRNA) regulates gene expression of osteoporosis (OS). It is known that miR-197-3p is abnormally expressed in osteoporosis. This study is to investigate the mechanism of miR-197-3p in regulating osteoblast differentiation.