Open Access<p>Increased Osteoblastic Cxcl9 Contributes to the Uncoupled Bone Formation and Resorption in Postmenopausal Osteoporosis</p>
Author(s) -
Zezheng Liu,
Wenquan Liang,
Dawei Kang,
Qingjing Chen,
Zhicong Ouyang,
Huibo Yan,
Bin Huang,
Dadi Jin,
Yinkui Chen,
Qingchu Li
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s254885
Subject(s) - osteoclast , bone resorption , medicine , endocrinology , ovariectomized rat , bone remodeling , osteoblast , resorption , chemistry , estrogen , receptor , in vitro , biochemistry
Estrogen deficiency leads to bone loss in postmenopausal osteoporosis, because bone formation, albeit enhanced, fails to keep pace with the stimulated osteoclastic bone resorption. The mechanism driving this uncoupling is central to the pathogenesis of postmenopausal osteoporosis, which, however, remains poorly understood. We previously found that Cxcl9 secreted by osteoblasts inhibited osteogenesis in bone, while the roles of Cxcl9 on osteoclastic bone resorption and osteoporosis are unclear.