Open Access<p>A Population-Based Propensity Score-Matched Study to Assess the Impact of Repeated Vaccination on Vaccine Effectiveness for Influenza-Associated Hospitalization Among the Elderly</p>
Author(s) -
Pi-Shan Hsu,
Ie-Bin Lian,
DayYu Chao
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s238786
Subject(s) - medicine , vaccination , propensity score matching , influenza vaccine , hazard ratio , population , cohort , immunology , confidence interval , environmental health
Influenza is a major cause of morbidity and mortality in the elderly worldwide. Influenza vaccination can prevent morbidity/mortality from influenza infection. A gap of 1-2 years, before an epidemic strain is recommended by the World Health Organization (WHO) to be the vaccine strain in Southeast Asia, has been reported; this results in a high rate of vaccine mismatch and excess influenza-associated morbidity. The aim of the current study was to evaluate the effect of repeated vaccination on vaccine effectiveness (VE) among the elderly in Taiwan, during years with and without early appearance of antigenically drifted strains.