Open AccessUsing the Systems Biology Approach and Molecular Method to Investigate the Role of the Dopaminergic Pathway in Osteoarthritis: A Case Control Study
Author(s) -
Mojgan Sheikhpour,
Darioush Eliaspour,
Iraj Arabi,
Seyed Ahmad Raeissadat,
Arezou Lari,
Tohid Seif Barghi
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s238351
Subject(s) - dopaminergic , osteoarthritis , dopamine , dopamine receptor , medicine , disease , dopaminergic pathways , transcriptome , gene , bioinformatics , gene expression , biology , genetics , pathology , alternative medicine
Osteoarthritis is the most common type of arthritis and one of the leading causes of job loss and motor disabilities. Recently, the involvement of dopaminergic pathways and dopamine receptor genes has been considered in this disease. Therefore, studying and comparing the expression pattern of these receptor genes can lead to a greater understanding of the pathogenesis of this disease.