Open Access<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>
Author(s) -
Edyta Zbroch,
Angelika Bazyluk,
Jolanta Małyszko,
Ewa Koc-Żórawska,
Alicja RydzewskaRosołowska,
Katarzyna Kakareko,
Tomasz Hryszko
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s236980
Subject(s) - klotho , medicine , renal function , hemodialysis , dialysis , endocrinology , kidney , kidney disease , diabetes mellitus , oxidative stress , end stage renal disease , blood pressure , type 2 diabetes
Sirtuin1 (SIRT1) acts as an anti-aging protein due to anti-apoptotic, anti-oxidative and anti-inflammatory effect and is implicated in several diseases including diabetes or cardiovascular problems. SIRT1 renal overexpression indicates oxidative stress. Similarly, αKlotho was primarily exposed as anti-aging factor. It is primary produced in kidney. It's deficiency is associated with progression of chronic kidney disease and heart disorders.