Open Access<p>Circulating α4β7<sup>+</sup> Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire</p>
Author(s) -
Adir Gamliel,
Lael Werner,
Marina Pinsker,
Naomi Salamon,
Batia Weiss,
Dror S. Shouval
Publication year - 2020
Publication title -
clinical and experimental gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s271565
Subject(s) - immunology , polyclonal antibodies , memory t cell , homing (biology) , repertoire , ulcerative colitis , cytotoxic t cell , t cell , medicine , antibody , biology , microbiology and biotechnology , disease , immune system , pathology , genetics , ecology , physics , acoustics , in vitro
The integrin α4β7 is highly expressed on activated T cells and is thought to direct homing of lymphocytes to the intestine. Since ulcerative colitis (UC) and Crohn's disease (CD) are characterized by mucosal oligoclonal T cells' expansion, we aimed to assess whether similar repertoire features are identified in circulating gut-specific memory T cells.