Open Access<p>Gut Dysbiosis and Increased Intestinal Permeability Drive microRNAs, NLRP-3 Inflammasome and Liver Fibrosis in a Nutritional Model of Non-Alcoholic Steatohepatitis in Adult Male Sprague Dawley Rats</p>
Author(s) -
Larisse Longo,
Jéssica Tonin Ferrari,
Pabulo Henrique Rampelotto,
Gustavo Hirata Dellavia,
Amanda Pasqualotto,
C.P. Oliveira,
Carlos Thadeu Schmidt Cerski,
Themis Reverbel da Silveira,
Carolina Uribe Cruz,
Mário Reis ÁlvaresdaSilva
Publication year - 2020
Publication title -
clinical and experimental gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s262879
Subject(s) - steatohepatitis , medicine , gut flora , intestinal permeability , endocrinology , steatosis , fatty liver , fibrosis , interleukin 10 , dysbiosis , cirrhosis , liver injury , gastroenterology , immunology , cytokine , disease
The interactions between the gut and liver have been described in the progression of non-alcoholic steatohepatitis (NASH). The aim of this study was to develop an experimental nutritional model of NASH simulating metabolic changes occurring in humans.