Open Access<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>
Author(s) -
Jagjeet Kaur,
Vasudha Sambyal,
Kamlesh Guleria,
Narendra Kumar Singh,
Manjit Singh Uppal,
Mridu Manjari,
Meena Sudan
Publication year - 2020
Publication title -
clinical and experimental gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s232961
Subject(s) - single nucleotide polymorphism , genotype , xrcc3 , xrcc1 , medicine , esophageal cancer , haplotype , gastroenterology , linkage disequilibrium , allele , multifactor dimensionality reduction , genetics , biology , gene , cancer
The X-ray repair cross-complementing ( XRCC) gene polymorphisms influence esophageal carcinogenesis by altering the DNA repair capacity. The present study was designed to screen five single nucleotide polymorphisms (SNPs) of XRCC genes for their susceptibility to esophageal cancer (EC) risk. There is no previous report on these polymorphisms for EC from India, where EC frequency is high.