Open Access<p>Estradiol accelerates liver regeneration through estrogen receptor α</p>
Author(s) -
Yoji Tsugawa,
Michiya Natori,
Hiroshi Handa,
Takeshi Imai
Publication year - 2019
Publication title -
clinical and experimental gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s214196
Subject(s) - estrogen receptor , liver regeneration , endocrinology , medicine , estrogen receptor alpha , regeneration (biology) , estrogen , steatosis , cancer research , biology , microbiology and biotechnology , cancer , breast cancer
Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced estrogen receptor alpha (ERα) expression. Methods: To further explore the role of ERα in estradiol-mediated liver regeneration, in the present study, we confirmed impaired liver regeneration ability in ERα knockout mice. Results: Further analysis during liver regeneration revealed a role for ERα in hepatic steatosis, tumor necrosis factor-alpha and interleukin 6 expression, and nuclear factor-κB and signal transducer and activator of transcription 3 DNA-binding activities. Conclusion: Moreover, estradiol administration accelerated liver regeneration through ERα, indicating the feasibility of the estrogen-ERα axis as a target for accelerating the rate of liver regeneration.