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The association between interferon lambda-3 ( IFNL3 also known as interleukin 28B, IL28B ) rs12979860 polymorphism and the development of hepatocellular carcinoma (HCC) has been investigated in recent studies with inconclusive and inconsistent results. IFNL3 rs12979860 polymorphism has been shown a marked differential distribution with regional and ethnic variation. Whether this single nucleotide polymorphism influences susceptibility to hepatitis C virus (HCV)-related HCC remains elusive.

clinical and experimental gastroenterology

&lt;p&gt;Association of &lt;em&gt;IFNL3&lt;/em&gt; rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population&lt;/p&gt;