Open AccessUVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through TRPA1 Channels
Author(s) -
Ying Liu,
Zhou Li,
Wei Wu,
Yupeng Wang,
Guangming Zhao,
Yuejian Liu,
Jing Liu,
Zhiqi Song
Publication year - 2022
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s365682
Subject(s) - hacat , phagocytosis , keratinocyte , microbiology and biotechnology , calcium in biology , melanin , biology , chemistry , transient receptor potential channel , intracellular , in vitro , receptor , biochemistry
Ultraviolet radiation (UVR) enhances skin pigmentation, which involves the production of melanin by melanocytes and subsequent transfer to keratinocytes. In the epidermis, keratinocyte phagocytosis plays a pivotal role in the process of melanosome transfer to protect DNA of epidermal cells against damage from UVR. Previous research suggested that transient receptor potential channels ankyrin 1 (TRPA1) was required for UVR-induced early melanin synthesis in melanocytes. Currently, there is no evidence that supports the detailed mechanism of TRPA1 for UVR-induced phagocytosis by keratinocytes. Here, we investigated the effect and the possible mechanisms of TRPA1 on keratinocyte phagocytosis and skin pigmentation after UVR exposure.