Open AccessExploring the Protective and Reparative Mechanisms of G. lucidum Polysaccharides Against H2O2-Induced Oxidative Stress in Human Skin Fibroblasts
Author(s) -
Xiuqin Shi,
Wenjing Cheng,
Qian Wang,
Jiachan Zhang,
Changtao Wang,
Long Meng,
Dan Zhao,
Dongdong Wang,
Quan An
Publication year - 2021
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s334527
Subject(s) - superoxide dismutase , keap1 , oxidative stress , antioxidant , chemistry , catalase , polysaccharide , reactive oxygen species , radical , biochemistry , glutathione peroxidase , malondialdehyde , human skin , glutathione , biology , enzyme , transcription factor , gene , genetics
Ganoderma lucidum ( G. lucidum ) is one of China's traditional medicinal materials. G. lucidum polysaccharide has a wide range of promising pharmacological applications. However, there are many kinds of G. lucidum and they contain different kinds of polysaccharides. The biological mechanism through which Ganoderma lucidum polysaccharides (GLP) is able to protect human skin fibroblasts (HSFs) from H 2 O 2 -induced oxidative damage is still unclear.