Open AccessAccelerated Barrier Repair in Human Skin Explants Induced with a Plant-Derived PPAR-α Activating Complex via Cooperative Interactions
Author(s) -
George Majewski,
John Craw,
Timothy J. Falla
Publication year - 2021
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s325967
Subject(s) - peroxisome proliferator activated receptor , microbiology and biotechnology , receptor , nuclear receptor , agonist , biology , chemistry , biochemistry , transcription factor , gene
Peroxisome proliferator-activated receptors (PPARs) govern epidermal lipid synthesis and metabolism. In skin, PPAR activation has been shown to regulate genes responsible for permeability barrier homeostasis, epidermal differentiation, lipid biosynthesis, and inflammation.