Open AccessKeratin 17 is Not Always a Marker of Proliferation of Keratinocytes in Skin Diseases
Author(s) -
Li Cui,
Zirong Zhu,
Feng Yan,
Yanfei Zhang
Publication year - 2021
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s322226
Subject(s) - immunohistochemistry , psoriasis , epidermolysis bullosa simplex , keratin , pathology , medicine , keratinocyte , dermatology , biology , cell culture , genetics
Keratin 17 (K17) is an embryonic keratin and overexpression is seen in psoriasis, which is a hyperproliferation skin disease. Nonetheless, whether it is also highly expressed in other proliferative skin diseases remains unclear. The aim of this study is to explore the expression of K17 in cutaneous lichen planus (CLP), lichen simplex chronicus (LSC), and prurigo nodularis (PN).