Open AccessRelationship of Substance P with the Degree of Atopic Dermatitis Severity
Author(s) -
Deryne Anggia Paramita,
Khairisution,
Nova Zairina Lubis
Publication year - 2021
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s306557
Subject(s) - scorad , itching , medicine , atopic dermatitis , substance p , gastroenterology , severity of illness , disease , immunology , dermatology life quality index , receptor , neuropeptide
Atopic dermatitis (AD) is a chronic inflammatory skin disease that starts during childhood with a varied course. Itching or incessant itching in severe cases, sleep disturbance, and infection-prone skin are the typical symptoms of this disease. Substance P is postulated to have an important role in AD. Increasing levels of substance P in AD induce the release of IFN-γ, IL-4, tumor necrosis factor-α (TNF-α), and IL-10 from peripheral blood mononuclear leukocytes, inducing an itching response.