Open AccessThe Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China
Author(s) -
Ting Yang,
Wenjuan Wu,
Liming Tian,
Dengfeng Zhang,
Xiao-Yan Yang,
Jue Qi,
Ying Tu,
Li He
Publication year - 2021
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s293171
Subject(s) - haplotype , acne , single nucleotide polymorphism , biology , gene , androgen , medicine , physiology , genetics , allele , genotype , hormone
Androgens acting through the androgen receptor play a crucial role in the pathogenesis of acne. This study aimed to identify whether two key genes ( CYP21A2 and CYP19A1 ) involved in the synthesis and metabolism of androgens were associated with Pillsbury III-IV severe acne vulgaris.