Open AccessAssessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study
Author(s) -
Essam Nada,
Eman M. S. Muhammad,
Safaa Ebrahim Ahmed,
Asmaa M S Tamam,
Amr Abdelhamed
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s284300
Subject(s) - psoriasis , psoriasis area and severity index , medicine , immunohistochemistry , autophagy , skin biopsy , metabolic syndrome , biopsy , dermatology , transepidermal water loss , pathology , gastroenterology , biology , apoptosis , biochemistry , stratum corneum , obesity
Psoriasis vulgaris, one of the most prevalent chronic inflammatory skin diseases, is associated with metabolic syndrome (MetS). Autophagy, an intracellular degradation system is essential for cell survival and differentiation, and its dysfunction may contribute to metabolic diseases. A cross-sectional study was conducted on 38 psoriasis vulgaris patients and 16 healthy control subjects to 1) Assess immunohistochemical (IHC) expression of microtubule-associated protein light chain 3 (LC3); 2) Evaluate the relationship between Psoriasis Area Severity Index (PASI) score, and LC3 expression.