Open Access<p>Effect of TNF-α <em>−308G/A (rs1800629)</em> Promoter Polymorphism on the Serum Level of TNF-α Among Iraqi Patients with Generalized Vitiligo</p>
Author(s) -
Ronak Ahmed,
Dana Ahmed Sharif,
Mohammad Jaf,
Dashty Mohammed Amin
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s272970
Subject(s) - vitiligo , tumor necrosis factor alpha , single nucleotide polymorphism , allele , medicine , immunology , gene polymorphism , gene , genotype , biology , genetics
Vitiligo is a chronic acquired pigmentary disorder of the skin; it results from immunological distruction of functioning melanocytes. The cytokine TNF-α plays a central role in the initiation of melanocyte apoptosis in vitiligo. Single nucleotide polymorphism (SNP) in the promoter region of the gene coding for serum TNF-α may affect its production.