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Vitiligo is a chronic acquired pigmentary disorder of the skin; it results from immunological distruction of functioning melanocytes. The cytokine TNF-α plays a central role in the initiation of melanocyte apoptosis in vitiligo. Single nucleotide polymorphism (SNP) in the promoter region of the gene coding for serum TNF-α may affect its production.

clinical cosmetic and investigational dermatology

&lt;p&gt;Effect of TNF-α &lt;em&gt;−308G/A (rs1800629)&lt;/em&gt; Promoter Polymorphism on the Serum Level of TNF-α Among Iraqi Patients with Generalized Vitiligo&lt;/p&gt;