Open Access<p>Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population</p>
Author(s) -
Azza Gaber Antar Farag,
Hesham N Khaled,
M. A. Hammam,
Mustafa Elsayed Elshaib,
Nermin Tayel,
Sahar Elsoudy Ibrahim Hommos,
Eman Masoud Abd El Gayed
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s253603
Subject(s) - keloid , genotype , allele , medicine , fibronectin , elastin , population , wound healing , extracellular matrix , fibrosis , hypertrophic scar , gastroenterology , pathology , microbiology and biotechnology , cancer research , gene , immunology , genetics , biology , environmental health
Keloids represent chronic fibroproliferative skin disorders in which there is deposition of extracellular components, especially type 1 collagen, fibronectin and elastin, in excessive amounts. NEDD4 is associated with fibrosis found in abnormal wound healing through increased fibroblast proliferation and regulation of type 1 collagen expression. The exact etiology of keloid formation is undefined, but the role of genetic factors was demonstrated.