Open Access<p>The Effectiveness of a New Topical Formulation Containing GSH-C4 and Hyaluronic Acid in Seborrheic Dermatitis: Preliminary Results of an Exploratory Pilot Study</p>
Author(s) -
Elena Campione,
Sara Mazzilli,
Caterina Lanna,
Terenzio Cosio,
Vincenzo Davide Palumbo,
Gaia Maria Cesaroni,
Flavia Lozzi,
Laura Diluvio,
Luca Bianchi
Publication year - 2019
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s231313
Subject(s) - tolerability , medicine , seborrheic dermatitis , dermatology , psoriasis , glutathione , itching , pharmacology , adverse effect , chemistry , biochemistry , enzyme
Seborrheic dermatitis is a common skin disease with clinical aspects similar to those of psoriasis, eczema or allergic reactions, appearing on the sebum-rich areas of the scalp, face, and trunk. Yeast like Malassezia species, immunologic abnormalities and activation of complement are recognized as a crucial pathogen for the onset of seborrheic dermatitis. Intermittent and active phases are characterized by burning, scaling and itching, then followed by inactive periods. The disease is sometimes severe up to the erythrodermia; thus, it has a great influence on the patient's quality of life. In vitro and vivo studies have shown that the exogenous intake of glutathione-GSH-C4 and tocopherol inhibits lipid peroxidation and effectively fights and reduces oxidative stress in inflammatory disorders.