Open Access<p>Role of Galectin-9 in Atopic Dermatitis — Is It Mediated Through E Selectin? A Clinical and Immunohistochemical Study</p>
Author(s) -
Azza Gaber Antar Farag,
Dalia Rifaat Al-Sharaky,
Sawsan Samy Allam,
Hesham N Khaled
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s229393
Subject(s) - immunohistochemistry , atopic dermatitis , galectin 3 , galectin , medicine , immunology
Atopic dermatitis (AD) is a recognized T helper (Th)2, allergic, skin disease. Galectin-9 (gal-9) is a member of galectin family. It alters T-cell balance resulting in Th2 polarization. These Th2 cells yield various cytokines that may influence E selectin expression. Therefore, we hypothesized that gal-9 may have an active role in AD and this role could be mediated through E selectin.